Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | CTSV | O60911 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4449804 | 0.76 | CTSK (0.44) | CTSKCTSSCTSVCTSL | |
| SCHEMBL7207843 | 0.75 | SMN1; SMN2 (0.39) | CTSKSMN1; SMN2POLBLMNATSHR | |
| SCHEMBL4449255 | 0.74 | CTSK (0.46) | CTSKSMN1; SMN2TSHRALDH1A1RECQL | |
| SCHEMBL4449860 | 0.71 | CTSK (0.45) | CTSKSMN1; SMN2POLBCTSSCTSV | |
| SCHEMBL4451966 | 0.71 | CTSK (0.49) | CTSKPOLBTSHRALDH1A1CTSS | |
| SCHEMBL4207796 | 0.71 | CTSK (0.47) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4456058 | 0.70 | CTSK (0.38) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4446620 | 0.69 | CTSK (0.47) | CTSKSMN1; SMN2ALDH1A1RECQLUSP2 | |
| SCHEMBL7018963 | 0.69 | CTSS (0.53) | CTSKSMN1; SMN2ALDH1A1CTSSCTSV | |
| SCHEMBL7017106 | 0.69 | CTSS (0.42) | CTSKLMNATSHRALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |