Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.53 |
| ▸ | CTSV | O60911 | 4/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016832 | 0.94 | CTSS (0.48) | CTSSCTSVCTSKCTSLACHE | |
| SCHEMBL7017106 | 0.85 | CTSS (0.42) | CTSSCTSVCTSKCTSLACHE | |
| SCHEMBL4451610 | 0.82 | CTSS (0.55) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7019912 | 0.80 | PREP (0.44) | CTSSCTSVCTSKCTSLACHE | |
| SCHEMBL4459112 | 0.76 | CTSS (0.50) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL4452668 | 0.76 | CTSK (0.62) | CTSSCTSVCTSKCTSLHPGD | |
| SCHEMBL4449804 | 0.75 | CTSK (0.44) | CTSSCTSVCTSKCTSL | |
| SCHEMBL4457938 | 0.75 | CTSS (0.47) | CTSSCTSVCTSKCTSLKDM4E | |
| SCHEMBL5255097 | 0.74 | CTSS (0.72) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7020985 | 0.73 | CTSK (0.46) | CTSSCTSVCTSKCTSLDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |