Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.87 |
| ▸ | EGFR | P00533 | 9/20 | 0.87 |
| ▸ | ABL1 | P00519 | 8/20 | 0.87 |
| ▸ | ABL2 | P42684 | 8/20 | 0.87 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.77 |
| ▸ | FGR | P09769 | 1/20 | 0.77 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.77 |
| ▸ | TXK | P42681 | 1/20 | 0.77 |
| ▸ | FRK | P42685 | 1/20 | 0.77 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.77 |
| ▸ | LCK | P06239 | 3/20 | 0.72 |
| ▸ | TEK | Q02763 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | NPM1 | P06748 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019904 | 0.93 | SRC (1.00) | SRCEGFRABL1ABL2RIPK2 | |
| Hydrochloric Acid SCHEMBL8107815 | 0.92 | SRC (0.98) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL13020337 | 0.88 | SRC (0.72) | SRCEGFRABL1ABL2RIPK2 | |
| Hydrochloric Acid SCHEMBL7098308 | 0.87 | SRC (0.85) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7018367 | 0.87 | FGR (1.00) | SRCEGFRABL1ABL2FGR | |
| SCHEMBL6867601 | 0.86 | SRC (0.80) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL8098939 | 0.85 | SRC (0.88) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL6465227 | 0.84 | SRC (1.00) | SRCEGFRABL1PTK6LCK | |
| SCHEMBL27397203 | 0.83 | SRC (0.67) | SRCEGFRABL1ABL2RIPK2 | |
| Hydrochloric Acid SCHEMBL6465660 | 0.83 | SRC (0.98) | SRCEGFRABL1PTK6LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |