Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020155 | 1.00 | ALDH1A1 (0.32) | ALDH1A1QPCTPI4KAPI4K2BPI4K2A | |
| SCHEMBL7022644 | 0.89 | QPCT (0.32) | ALDH1A1QPCTPI4KAPI4K2BPI4K2A | |
| SCHEMBL7022645 | 0.89 | QPCT (0.32) | ALDH1A1QPCTPI4KAPI4K2BPI4K2A | |
| SCHEMBL7024008 | 0.75 | ALDH1A1 (0.33) | ALDH1A1QPCTLMNAHPGDMAPK1 | |
| SCHEMBL7024004 | 0.75 | ALDH1A1 (0.33) | ALDH1A1QPCTLMNAHPGDMAPK1 | |
| SCHEMBL7015566 | 0.75 | XDH (0.44) | ALDH1A1LMNAHPGD | |
| SCHEMBL7015562 | 0.75 | XDH (0.44) | ALDH1A1LMNAHPGD | |
| SCHEMBL7027041 | 0.74 | ADORA3 (0.37) | — | |
| SCHEMBL7027036 | 0.74 | ADORA3 (0.37) | — | |
| SCHEMBL7020401 | 0.74 | QPCT (0.35) | ALDH1A1QPCTLMNAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |