Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGR | P09769 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091675 | 0.90 | NPSR1 (0.47) | SIRT5MAPTMERTKKDM4EALDH1A1 | |
| SCHEMBL7852303 | 0.89 | MERTK (0.36) | SIRT5MAPTMERTKFLT3ZAP70 | |
| SCHEMBL27559810 | 0.85 | GSK3B (0.46) | SIRT5MAPTMERTKZAP70SYK | |
| SCHEMBL5100065 | 0.81 | POLB (0.49) | SIRT5MAPTMERTKJAK2ABL1 | |
| SCHEMBL5092032 | 0.81 | GSK3B (0.44) | MAPTKDM4EALDH1A1GAAMAPK8 | |
| SCHEMBL5093156 | 0.80 | ALDH1A1 (0.39) | SIRT5MAPTMERTKFLT3KDM4E | |
| SCHEMBL7021332 | 0.80 | EIF4E (0.38) | SIRT5MAPTMERTKFLT3ZAP70 | |
| SCHEMBL27559808 | 0.79 | EIF4E (0.39) | SIRT5MAPTMERTKZAP70SYK | |
| SCHEMBL6086128 | 0.77 | SMN1; SMN2 (0.47) | MAPTSTAT6KDM4EALDH1A1GAA | |
| SCHEMBL7843791 | 0.76 | SIRT5 (0.45) | SIRT5MAPTPRKCQKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |