Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100065 | 0.94 | POLB (0.49) | SIRT5POLBSMN1; SMN2EGFRHTT | |
| SCHEMBL5100068 | 0.80 | SMN1; SMN2 (0.70) | SIRT5POLBSMN1; SMN2EGFRHTT | |
| SCHEMBL7853508 | 0.80 | MAPT (0.58) | SIRT5POLBSMN1; SMN2EGFRHTT | |
| SCHEMBL6087097 | 0.79 | SIRT5 (0.54) | SIRT5POLBSMN1; SMN2EGFRHTT | |
| SCHEMBL7020535 | 0.76 | SIRT5 (0.46) | SIRT5MAPTPRKCQKDM4EALDH1A1 | |
| SCHEMBL507660 | 0.73 | NTRK1 (0.56) | POLBSMN1; SMN2KDM4ELMNAMAPK1 | |
| SCHEMBL5091675 | 0.72 | NPSR1 (0.47) | SIRT5POLBSMN1; SMN2HTTMAPT | |
| SCHEMBL5759562 | 0.68 | POLB (0.55) | SIRT5POLBSMN1; SMN2EGFRHTT | |
| SCHEMBL18319382 | 0.68 | MAPT (0.64) | SIRT5EGFRHTTMAPTPRKCQ | |
| SCHEMBL29392518 | 0.68 | FGFR4 (0.49) | HTTMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |