Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342091 | 0.90 | BDKRB2 (0.45) | POLBALDH1A1NPSR1BDKRB2ALOX5 | |
| SCHEMBL7342093 | 0.90 | BDKRB2 (0.45) | POLBALDH1A1NPSR1BDKRB2ALOX5 | |
| SCHEMBL7015459 | 0.90 | POLB (0.47) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL7015458 | 0.90 | POLB (0.47) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL2298566 | 0.90 | POLB (0.47) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL7020805 | 0.89 | ALDH1A1 (0.48) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL7020775 | 0.89 | ALDH1A1 (0.48) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL8999682 | 0.86 | POLB (0.43) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL7021955 | 0.85 | MCL1 (0.45) | POLBALDH1A1NPSR1TP53KDM4E | |
| SCHEMBL7021952 | 0.85 | MCL1 (0.45) | POLBALDH1A1NPSR1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672665-B1 | Antithrombotic agents | LILLY CO ELI (US) | 2001-02-07 | — | — | EP | disclosed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5578574-A | THROMBIN INHIBITORS OR ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0672665-A1 | Antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5436229-A | Di- and tripeptides as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | disclosed |