Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 11/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804689 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL7016849 | 0.80 | PDE7A (0.39) | ELANEPARP1PARP14CASRHRH3 | |
| SCHEMBL7016000 | 0.74 | PDE7A (0.40) | ALDH1A1 | |
| SCHEMBL7016857 | 0.71 | MAPK1 (0.41) | KDM4EALDH1A1GAA | |
| SCHEMBL7011912 | 0.66 | ELANE (0.46) | PIK3CDELANEPARP1CASRHRH3 | |
| SCHEMBL1161604 | 0.66 | PIK3CD (0.50) | PIK3CDELANEPARP1CASRHRH3 | |
| SCHEMBL7014708 | 0.66 | ELANE (0.49) | PIK3CDELANEPARP1CASRHRH3 | |
| SCHEMBL7013206 | 0.64 | SMN1; SMN2 (0.49) | PIK3CDELANEPARP1CASR | |
| SCHEMBL16596954 | 0.63 | GAA (0.56) | PIK3CDELANEPARP1HRH3KCNH2 | |
| SCHEMBL7016775 | 0.63 | ELANE (0.46) | PIK3CDELANEPARP1CASRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |