SCHEMBL70212

SCHEMBL70212

Cc1c(Cl)cc(Cl)c(O)c1Cc1c(C)c(Cl)cc(Cl)c1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 5/20 0.63
SMN1; SMN2 Q16637 4/20 0.63
CYP2C19 P33261 3/20 0.63
CYP2C9 P11712 2/20 0.63
TP53 P04637 1/20 0.63
HSD17B10 Q99714 8/20 0.61
HPGD P15428 8/20 0.61
TSHR P16473 4/20 0.61
CASP7 P55210 4/20 0.61
MAPK1 P28482 2/20 0.61
CYP3A4 P08684 2/20 0.61
RECQL P46063 2/20 0.61
MAPT P10636 2/20 0.61
THRB P10828 2/20 0.61
HTT P42858 2/20 0.61
CYP1A2 P05177 2/20 0.61
ALOX15 P16050 2/20 0.61
ALOX12 P18054 2/20 0.61
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8822888 0.83 HSD17B10 (0.76) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
Biclotymol SCHEMBL31496050 0.82 HIF1A (0.54) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
Biclotymol SCHEMBL70634 0.82 HIF1A (0.54) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
SCHEMBL70468 0.78 CYP2C19 (1.00) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
SCHEMBL19235936 0.77 CYP2C19 (0.49) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
Hexachlorophene SCHEMBL15579 0.76 HSD17B10 (1.00) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
Hexachlorophene SCHEMBL29352805 0.76 HSD17B10 (1.00) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
SCHEMBL23543131 0.76 SIRT1 (0.89) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
SCHEMBL25828290 0.75 HSD17B10 (0.48) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53
SCHEMBL13287028 0.75 SIRT1 (0.86) HIF1ASMN1; SMN2CYP2C19CYP2C9TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 HIF1A 1324/4885SMN1; SMN2 4357/4885CYP2C19 3009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.