SCHEMBL7021385

SCHEMBL7021385

CCc1c(OCc2ccccc2)ccc(P(=O)(O)O)c1CC

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALPG P10696 1/20 0.61
PTK2B Q14289 1/20 0.61
MAPK14 Q16539 1/20 0.48
TSHR P16473 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
LIPE Q05469 1/20 0.42
MAPT P10636 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MAPK1 P28482 1/20 0.41
SMPD1 P17405 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CETP P11597 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7020517 0.84 ALPG (0.51) ALPGPTK2BMAPK14TSHRSMN1; SMN2
SCHEMBL9355431 0.77 PTK2B (1.00) ALPGPTK2BTSHRNPC1RAB9A
SCHEMBL2859514 0.76 ALPG (0.59) ALPGPTK2BTSHRSMN1; SMN2NPC1
SCHEMBL19704875 0.73 SMN1; SMN2 (0.49) MAPK14SMN1; SMN2NPC1HPGDRAB9A
SCHEMBL7020521 0.71 ALPG (0.43) ALPGPTK2BMAPK14TSHRSMN1; SMN2
SCHEMBL17746154 0.71 POLB (0.38) ALPGPTK2BSMN1; SMN2NPC1HPGD
SCHEMBL3701442 0.71 PTGER1 (0.60) MAPK14NPC1MAPTTDP1L3MBTL1
SCHEMBL16095408 0.70 ERN1 (0.50) MAPK14SMN1; SMN2NPC1HPGDRAB9A
SCHEMBL28001337 0.70 ALPG (0.41) ALPGPTK2BTSHRCETPLMNA
SCHEMBL8026516 0.70 SMN1; SMN2 (0.41) PTK2BSMN1; SMN2NPC1MAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574174-B1 Angiotensin II antagonists LILLY CO ELI (US) 2003-08-13 EP disclosed
US-5693633-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1997-12-02 US disclosed
US-5612360-A AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5556981-A Angiotensin II antagonist intermediates ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
US-5484780-A CARDIOVASCULAR, HYPOTENSIVE ELI LILLY AND COMPANY (US) 1996-01-16 US disclosed
US-5401851-A Preparation of proline derivatives ELI LILLY AND COMPANY (US) 1995-03-28 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed
EP-0573271-A1 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-08 EP disclosed