Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705426 | 0.92 | CTSD (0.46) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL2394509 | 0.89 | MAPT (0.56) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL4416634 | 0.82 | FOLH1 (0.58) | SMN1; SMN2MAPTCYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL6933049 | 0.82 | CTSD (0.58) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL6938240 | 0.81 | CTSD (0.48) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL5213152 | 0.81 | SGMS2 (0.51) | SMN1; SMN2MAPTTDP1L3MBTL1HPGD | |
| SCHEMBL19610526 | 0.80 | HPGD (0.57) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL978857 | 0.79 | HTT (0.64) | SMN1; SMN2MAPTL3MBTL1LMNANPC1 | |
| SCHEMBL31220629 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 | |
| SCHEMBL19610500 | 0.78 | HPGD (0.58) | SMN1; SMN2MAPTCYP2C9CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214335-A1 | ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES | ABBVIE INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2017214458-A2 | ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES | ABBVIE INC. (US) | 2017-12-14 | — | — | WO | disclosed |