Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 0.86 |
| ▸ | MTNR1B | P49286 | 15/20 | 0.86 |
| ▸ | NQO2 | P16083 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970691 | 0.89 | MTNR1A (0.76) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL5223857 | 0.89 | MTNR1A (0.72) | MTNR1AMTNR1BNQO2HTR1AHTR2C | |
| SCHEMBL6076698 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL5223865 | 0.80 | MTNR1A (0.63) | MTNR1AMTNR1BNQO2HTR1AHTR2C | |
| SCHEMBL5231694 | 0.78 | MTNR1A (0.58) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7022012 | 0.77 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2HTR1A | |
| SCHEMBL132847 | 0.77 | MTNR1A (0.66) | MTNR1AMTNR1BNQO2HTR2C | |
| SCHEMBL5226600 | 0.77 | MTNR1A (0.65) | MTNR1AMTNR1BNQO2HTR1AHTR2C | |
| SCHEMBL7017326 | 0.76 | MTNR1A (0.75) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7198659 | 0.76 | MTNR1A (0.69) | MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635650-B2 | Such as N-(2-(7-(2-((8-(2-(acetyl-amino)ethyl)-2-naphthyl) oxy)ethoxy)-1-napthyl)ethyl)acetamide for treating or preventing melatoninergic disorders | LES LABORATOIRES SERVIER (FR) | 2003-10-21 | — | — | US | disclosed |
| EP-1038863-B1 | Substituted dimeric compounds, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | disclosed |
| US-6319930-B1 | CONTAINING FUSED AROMATIC CARBO- OR HETEROCYCLIC RINGS AND AMIDE, THIOAMIDE, UREA OR THIOUREA GROUPS; USEFUL IN TREATING OR IN PREVENTING MELATONINERGIC DISORDERS. | ADIR ET COMPAGNIE (FR) | 2001-11-20 | — | — | US | disclosed |
| EP-1038863-A2 | Substituted dimeric compounds, process for their preparation and pharmaceutical compositions thereof | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |