Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11694117 | 0.89 | LMNA (0.71) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL11694106 | 0.89 | LMNA (0.71) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL8840026 | 0.85 | ESR1 (0.71) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL8432580 | 0.85 | ESR1 (0.71) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL7076832 | 0.84 | LMNA (0.67) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL10079788 | 0.84 | LMNA (0.77) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL13015302 | 0.84 | LMNA (0.77) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| Estradiol Methyl Ether SCHEMBL23645792 | 0.83 | HSD17B10 (1.00) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL2713500 | 0.83 | LMNA (0.76) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL23645808 | 0.83 | LMNA (0.76) | LMNAHSD17B10ESR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135403-B1 | 17BETA-ACYL-17ALPHA-PROPYNYL-11BETA-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES | RES TRIANGLE INST (US) | 2003-07-30 | — | — | EP | disclosed |
| EP-1135403-A4 | 17BETA-ACYL-17ALPHA-PROPYNYL-11BETA-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES | RES TRIANGLE INST (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1135403-A1 | 17BETA-ACYL-17ALPHA-PROPYNYL-11BETA-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6172052-B1 | ANTITUMOR AGENTS, HORMONE REPLACEMENT THERAPY, ANTIPROGESTATION ACTIVITY | RESEARCH TRIANGLE INSTITUTE | 2001-01-09 | — | — | US | disclosed |
| WO-2000034306-A1 | 17β-ACYL-17α-PROPYNYL-11β-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES | RESEARCH TRIANGLE INSTITUTE (US) | 2000-06-15 | — | — | WO | disclosed |