Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.76 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87697 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL4056092 | 0.85 | — | — | |
| Sulfamide SCHEMBL27834517 | 0.79 | AURKA (0.83) | AURKAAURKBINCENPNAPRTDAO | |
| Formamide SCHEMBL17503641 | 0.79 | AURKA (0.83) | AURKAAURKBINCENPNAPRTDAO | |
| SCHEMBL7642912 | 0.76 | AURKA (0.76) | AURKAAURKBINCENPNAPRTDAO | |
| Anthranilamide SCHEMBL5170575 | 0.74 | AURKA (0.55) | AURKAAURKBINCENPNAPRTDAO | |
| SCHEMBL3182033 | 0.71 | NAPRT (0.67) | AURKAAURKBINCENPNAPRTDAO | |
| SCHEMBL82637 | 0.71 | NAPRT (0.67) | AURKAAURKBINCENPNAPRTDAO | |
| Acetamide SCHEMBL7526547 | 0.71 | FKBP5 (0.70) | AURKAAURKBINCENPNAPRTDAO | |
| SCHEMBL3831213 | 0.71 | AURKA (0.66) | AURKAAURKBINCENPDAOPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997474-B1 | Antithrombotic agents | PFIZER (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | disclosed |