Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.50 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 12/20 | 0.47 |
| ▸ | RXRB | P28702 | 8/20 | 0.47 |
| ▸ | RXRG | P48443 | 7/20 | 0.47 |
| ▸ | RARA | P10276 | 5/20 | 0.47 |
| ▸ | RARB | P10826 | 5/20 | 0.47 |
| ▸ | RARG | P13631 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023941 | 0.82 | RXRA (0.57) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL1074782 | 0.76 | RXRA (0.62) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL7121488 | 0.75 | MEN1 (0.45) | DEGS1CYP26A1CYP26B1RXRARXRB | |
| SCHEMBL8445083 | 0.75 | CYP26A1 (0.73) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL8336184 | 0.75 | CYP26A1 (0.56) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL727916 | 0.74 | RXRA (0.70) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL7761497 | 0.73 | MAOA (0.48) | DEGS1RXRARARBMEN1KMT2A | |
| SCHEMBL7761494 | 0.73 | MAOA (0.48) | DEGS1RXRARARBMEN1KMT2A | |
| SCHEMBL292500 | 0.73 | RXRA (0.83) | CYP26A1CYP26B1RXRARXRBRXRG | |
| SCHEMBL7029044 | 0.73 | RXRA (0.56) | CYP26A1CYP26B1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832081-B1 | BICYCLIC-AROMATIC COMPOUNDS | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-01-29 | — | — | EP | claimed |
| EP-0832081-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1998-04-01 | — | — | EP | claimed |
| WO-1997033881-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | claimed |
| EP-0832081-B1 | BICYCLIC-AROMATIC COMPOUNDS | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-01-29 | — | — | EP | disclosed |
| EP-0832081-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1998-04-01 | — | — | EP | disclosed |
| WO-1997033881-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | disclosed |