Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250125 | 0.86 | GSK3B (0.46) | HTR7ALDH1A1POLBSMN1; SMN2DPP4 | |
| SCHEMBL7853884 | 0.85 | SMN1; SMN2 (0.35) | ALDH1A1POLBSMN1; SMN2DPP4GSK3B | |
| SCHEMBL7022502 | 0.84 | MEN1 (0.43) | ALDH1A1POLBSMN1; SMN2GSK3BMKNK1 | |
| SCHEMBL7855802 | 0.79 | MAPT (0.41) | ALDH1A1POLBSMN1; SMN2GSK3BMAPT | |
| SCHEMBL7852739 | 0.78 | GSK3B (0.38) | ALDH1A1POLBSMN1; SMN2GSK3BMAPT | |
| SCHEMBL4970607 | 0.78 | GSK3B (0.55) | ALDH1A1POLBSMN1; SMN2GSK3BNPBWR1 | |
| SCHEMBL7022814 | 0.78 | MAPT (0.39) | ALDH1A1POLBSMN1; SMN2GSK3BNPBWR1 | |
| SCHEMBL7850973 | 0.76 | GSK3B (0.40) | ALDH1A1POLBSMN1; SMN2GSK3BMAPT | |
| SCHEMBL7253650 | 0.71 | GSK3B (0.46) | ALDH1A1POLBSMN1; SMN2DPP4GSK3B | |
| SCHEMBL7852170 | 0.70 | GSK3B (0.60) | ALDH1A1POLBSMN1; SMN2GSK3BMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |