Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.56 |
| ▸ | OGFRL1 | Q5TC84 | 7/20 | 0.56 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | RB1 | P06400 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706789 | 0.90 | OPRM1 (0.56) | OPRM1OGFRL1ALDH1A1HTR1DHTR1B | |
| SCHEMBL698643 | 0.86 | OPRM1 (0.61) | OPRM1OGFRL1SSTR3SIRT1RB1 | |
| SCHEMBL699857 | 0.79 | OPRM1 (0.58) | OPRM1OGFRL1SIRT1RB1 | |
| SCHEMBL699418 | 0.78 | OPRM1 (0.57) | OPRM1OGFRL1SIRT1RB1 | |
| SCHEMBL699256 | 0.77 | OPRM1 (0.62) | OPRM1OGFRL1 | |
| SCHEMBL699217 | 0.76 | OPRM1 (0.56) | OPRM1OGFRL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL709906 | 0.75 | OPRM1 (0.54) | OPRM1OGFRL1ALDH1A1HTR1DHTR1B | |
| Citric Acid SCHEMBL699659 | 0.72 | OPRM1 (0.54) | OPRM1OGFRL1SSTR3ALDH1A1SIRT1 | |
| SCHEMBL682556 | 0.72 | OPRM1 (1.00) | OPRM1OGFRL1 | |
| SCHEMBL698663 | 0.71 | OPRM1 (0.61) | OPRM1OGFRL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124788-B2 | Spirocyclic cyclohexane compounds with analgesic activity | GRUENENTHAL GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20090111842-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS WITH ANALGESIC ACTIVITY | GRUENENTHAL GMBH (DE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111842-A1 | SPIROCYCLIC CYCLOHEXANE COMPOUNDS WITH ANALGESIC ACTIVITY | OPRK1, OPRL1, OPRD1 | OPRM1 9/4885OGFRL1 163/4885SSTR3 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.