Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016473 | 0.80 | KMT2A (0.46) | KMT2ARAB9ANPC1MEN1GAA | |
| Hydrochloric Acid SCHEMBL6085781 | 0.77 | GAA (0.43) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL2681134 | 0.77 | SMN1; SMN2 (0.56) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL30648848 | 0.77 | SMN1; SMN2 (0.56) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL10707768 | 0.75 | ALDH1A1 (0.55) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL7017028 | 0.75 | MEN1 (0.53) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL9794274 | 0.75 | SMN1; SMN2 (0.53) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL17198268 | 0.74 | MEN1 (0.55) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL30716729 | 0.74 | ALDH1A1 (0.60) | KMT2ARAB9ANPC1MEN1GAA | |
| SCHEMBL3018141 | 0.74 | ALDH1A1 (0.60) | KMT2ARAB9ANPC1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |