Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023019 | 0.80 | KMT2A (0.48) | KMT2ARAB9AMEN1NPC1GAA | |
| Hydrochloric Acid SCHEMBL5089382 | 0.79 | GAA (0.42) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL7017028 | 0.79 | MEN1 (0.53) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL10707768 | 0.76 | ALDH1A1 (0.55) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL7020671 | 0.75 | SMN1; SMN2 (0.49) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL17198268 | 0.72 | MEN1 (0.55) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL30716729 | 0.72 | ALDH1A1 (0.60) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL3018141 | 0.72 | ALDH1A1 (0.60) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL13229215 | 0.71 | HCAR3 (0.56) | KMT2ARAB9AMEN1NPC1GAA | |
| SCHEMBL2791677 | 0.71 | HCAR3 (0.56) | KMT2ARAB9AMEN1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |