SCHEMBL7023562

SCHEMBL7023562

FC(F)=CCCSC1=NCCS1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.40
HPGD P15428 4/20 0.39
ALDH1A1 P00352 5/20 0.37
MAPT P10636 5/20 0.37
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
ALOX12 P18054 1/20 0.36
APOBEC3A P31941 1/20 0.36
KMT2A Q03164 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PKM P14618 1/20 0.35
GFER P55789 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6244223 0.77 LMNA (0.39) LMNAHPGDALDH1A1MAPTMEN1
SCHEMBL3289759 0.70
SCHEMBL11215433 0.70
SCHEMBL8906308 0.69 LMNA (0.42) LMNAHPGDALDH1A1MAPTMEN1
SCHEMBL11617585 0.68 ALOX15 (0.42) LMNAHPGDALDH1A1MAPTKMT2A
SCHEMBL7020542 0.67 APEX1 (0.46) ALDH1A1POLBKMT2ANPC1RAB9A
SCHEMBL3296119 0.67 SMN1; SMN2 (0.46) LMNAHPGDALDH1A1MAPTMEN1
SCHEMBL3289898 0.66 SMN1; SMN2 (0.44) LMNAHPGDALDH1A1MAPTMEN1
SCHEMBL8906298 0.66 LMNA (0.42) LMNAHPGDALDH1A1MAPTMEN1
SCHEMBL8907250 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed