Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7030061 | 1.00 | MAPT (0.54) | MAPTRAB9AMTNR1AMTNR1BKCNH2 | |
| SCHEMBL7021228 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL7021230 | 0.88 | MTNR1A (0.50) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL7030412 | 0.88 | MTNR1A (0.54) | MAPTMTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL7030407 | 0.88 | MTNR1A (0.54) | MAPTMTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL7027929 | 0.87 | MTNR1A (0.65) | RAB9AMTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL7027930 | 0.87 | MTNR1A (0.65) | RAB9AMTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL7024053 | 0.87 | DRD2 (0.50) | MTNR1AMTNR1BKCNH2SCN9ASCN5A | |
| SCHEMBL7025324 | 0.87 | MTNR1A (0.49) | RAB9AMTNR1AMTNR1BKCNH2SCN9A | |
| SCHEMBL7025317 | 0.87 | MTNR1A (0.49) | RAB9AMTNR1AMTNR1BKCNH2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | claimed |
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |
| EP-0888319-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | Astra Aktiebolag (SE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034883-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-09-25 | — | — | WO | disclosed |