Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.79 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.79 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.79 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.60 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016981 | 0.94 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL7018039 | 0.92 | ABCC9 (0.81) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL7026651 | 0.91 | ABCC9 (0.80) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL4261594 | 0.91 | ABCC9 (0.82) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL4254889 | 0.89 | ABCC9 (0.98) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL726268 | 0.88 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL29387853 | 0.88 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL4254888 | 0.87 | ABCC9 (0.98) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL7018076 | 0.86 | NLRP3 (0.71) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL6567790 | 0.85 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11NLRP3DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100775-B1 | 2,5-SUBSTITUTED BENZOLSULFONYLUREAS AND THIOUREAS, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | AVENTIS PHARMA GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6410573-B1 | CARDIOVASCULAR DISEASES; POTASSIUM CHANNEL MODULATOR | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-25 | — | — | US | disclosed |