Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.98 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.98 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.98 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.67 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clamikalant SCHEMBL726268 | 0.99 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL29387853 | 0.99 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| Clamikalant SCHEMBL4254888 | 0.98 | ABCC9 (0.98) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL6567790 | 0.93 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL3765246 | 0.93 | ABCC9 (0.88) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL726272 | 0.92 | ABCC9 (0.87) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL6567784 | 0.91 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL7016981 | 0.91 | ABCC9 (0.85) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL7018854 | 0.90 | ABCC9 (0.82) | ABCC9ABCC8KCNJ11NLRP3DNMT3A | |
| SCHEMBL4261594 | 0.90 | ABCC9 (0.82) | ABCC9ABCC8KCNJ11NLRP3DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012067-A1 | Modulation of Hypothalamic Atp-Sensitive Potassium Channels | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2009-01-08 | — | — | US | disclosed |
| US-20070026079-A1 | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels | DARA BIOSCIENCES, INC. | 2007-02-01 | — | — | US | disclosed |
| EP-1117409-B1 | BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-BLOCKERS FOR THE TREATMENT OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM | AVENTIS PHARMA GMBH (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-6414030-B1 | 1-((5-(2-(5-TERT-BUTYL-2-METHOXYBENZAMIDO)ETHYL)-2-METHOXYPHEN YL)-SULFONYL)-3-METHYLTHIOUREA AND PROPANOLOL FOR EXAMPLE | AVENTIS PHARMA DEUTSCHLAND, GMBH (DE) | 2002-07-02 | — | — | US | disclosed |
| US-20020082300-A1 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM AND USE OF BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-RECEPTOR BLOCKERS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-06-27 | — | — | US | disclosed |
| EP-1117409-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM | Aventis Pharma Deutschland GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000015204-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM AND USE OF BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-RECEPTOR BLOCKERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082300-A1 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM AND USE OF BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-RECEPTOR BLOCKERS | UTS2R, TST, SIGMAR1 | ABCC9 340/4885ABCC8 196/4885KCNJ11 252/4885 |
| US-20090012067-A1 | Modulation of Hypothalamic Atp-Sensitive Potassium Channels | PYGB, PC, KCNN3 | ABCC9 384/4885ABCC8 415/4885KCNJ11 18/4885 |
| US-20070026079-A1 | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels | PC, LIPE, ATP5ME | ABCC9 482/4885ABCC8 605/4885KCNJ11 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.