Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026573 | 0.86 | HTR2A (0.53) | OPRM1TMEM97HTR2AGRM2HTR2C | |
| SCHEMBL7030073 | 0.81 | OPRM1 (0.49) | OPRM1TMEM97HTR2AHTR2CHTR7 | |
| SCHEMBL7029871 | 0.81 | HTR2A (0.47) | OPRM1TMEM97HTR2AHTR2CHTR7 | |
| SCHEMBL7031291 | 0.79 | OPRM1 (0.49) | OPRM1TMEM97HTR2AGRM2HTR2C | |
| SCHEMBL7022880 | 0.79 | HTR2A (0.53) | TMEM97HTR2AGRM2HTR2CDRD2 | |
| SCHEMBL7023753 | 0.78 | HTR2A (0.50) | HTR2AGRM2HTR2CHTR7HTR6 | |
| SCHEMBL7023957 | 0.78 | HTR2A (0.49) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7022347 | 0.76 | HTR2A (0.50) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL7024132 | 0.76 | HTR2A (0.47) | TMEM97HTR2AHTR2CHTR7DRD2 | |
| SCHEMBL4232561 | 0.75 | HTR2A (0.64) | OPRM1TMEM97HTR2AGRM2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | HTR2A, HTR1A, HTR5A | OPRM1 37/4885TMEM97 150/4885HTR2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.