Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 8/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026082 | 0.85 | CASP6 (0.38) | — | |
| SCHEMBL4395865 | 0.84 | TRPV1 (0.36) | MRGPRX4FPR2 | |
| SCHEMBL18988980 | 0.83 | MPL (0.44) | FEN1ALOX5APMRGPRX4MPLCYP11B2 | |
| SCHEMBL29755488 | 0.83 | MPL (0.44) | FEN1ALOX5APMRGPRX4MPLCYP11B2 | |
| SCHEMBL7020750 | 0.81 | TRPA1 (0.38) | — | |
| SCHEMBL7844485 | 0.75 | NISCH (0.41) | — | |
| SCHEMBL4972450 | 0.72 | GSK3B (0.44) | HSD11B1 | |
| SCHEMBL7023008 | 0.72 | NISCH (0.43) | — | |
| SCHEMBL7024613 | 0.70 | CSNK1A1 (0.40) | — | |
| SCHEMBL27481658 | 0.70 | MRGPRX4 (0.43) | FEN1ALOX5APMRGPRX4FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |