Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.51 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838593 | 0.85 | TRPA1 (0.44) | LPAR1LPAR5TRPA1HPGDALDH1A1 | |
| SCHEMBL19254236 | 0.83 | TAS2R14 (0.42) | LPAR1LPAR5LMNAALDH1A1NPSR1 | |
| SCHEMBL15066203 | 0.83 | TAS2R14 (0.42) | LPAR1LPAR5LMNAALDH1A1NPSR1 | |
| SCHEMBL16678775 | 0.83 | ALDH1A1 (0.47) | LMNAALDH1A1NPSR1CYP1A2TSHR | |
| SCHEMBL16678573 | 0.83 | ALDH1A1 (0.47) | LMNAALDH1A1NPSR1CYP1A2TSHR | |
| SCHEMBL16678574 | 0.83 | ALDH1A1 (0.47) | LMNAALDH1A1NPSR1CYP1A2TSHR | |
| SCHEMBL1529702 | 0.82 | MME (0.42) | LPAR1LPAR5TRPA1LMNAHPGD | |
| SCHEMBL24323256 | 0.81 | HDAC3 (0.50) | LPAR1LPAR5 | |
| SCHEMBL29059434 | 0.81 | HDAC3 (0.50) | LPAR1LPAR5 | |
| SCHEMBL15671079 | 0.80 | ABCB1 (0.48) | LMNAALDH1A1NPSR1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997474-B1 | Antithrombotic agents | PFIZER (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | disclosed |