SCHEMBL7027893

SCHEMBL7027893

CCCC1COC(c2ccc(-c3ccc(CCO)c(F)c3)cc2)OC1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.31
RARB P10826 3/20 0.30
RARA P10276 2/20 0.30
RARG P13631 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7028220 0.93 ESR2 (0.35) RORCRARBRARARARG
SCHEMBL7027472 0.92 RARB (0.35) RARBRARARARG
SCHEMBL7027934 0.87 FASN (0.32)
SCHEMBL7031004 0.85
SCHEMBL7027891 0.85 NAAA (0.34)
SCHEMBL10501646 0.81 QPCT (0.30)
SCHEMBL8456026 0.81 FASN (0.33)
SCHEMBL7031164 0.81 CYP2C9 (0.46)
SCHEMBL7029907 0.81 RORC (0.30) RORC
SCHEMBL7026192 0.81 ESR2 (0.33) RARBRARARARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754668-B1 Fluorobenzylether derivatives ROLIC AG (CH) 2003-02-05 EP disclosed
EP-0754668-A2 Fluorobenzylether derivatives Rolic AG (CH) 1997-01-22 EP disclosed