Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 8/20 | 0.61 |
| ▸ | ACE | P12821 | 7/20 | 0.61 |
| ▸ | CPA1 | P15085 | 7/20 | 0.61 |
| ▸ | ACE2 | Q9BYF1 | 7/20 | 0.61 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032146 | 1.00 | MME (0.61) | MMEACECPA1ACE2LTA4H | |
| SCHEMBL7028034 | 0.87 | MME (0.72) | MMEACECPA1ACE2 | |
| SCHEMBL7031211 | 0.85 | MME (0.68) | MMEACECPA1ACE2LTA4H | |
| SCHEMBL7029391 | 0.85 | MME (0.68) | MMEACECPA1ACE2LTA4H | |
| SCHEMBL7029386 | 0.85 | MME (0.68) | MMEACECPA1ACE2LTA4H | |
| SCHEMBL8836882 | 0.84 | GNPAT (0.61) | MMELTA4H | |
| SCHEMBL7032097 | 0.84 | MME (0.71) | MMEACECPA1ACE2 | |
| SCHEMBL7032093 | 0.84 | MME (0.71) | MMEACECPA1ACE2 | |
| SCHEMBL7026577 | 0.84 | LTA4H (0.53) | MMELTA4H | |
| SCHEMBL7026556 | 0.84 | LTA4H (0.53) | MMELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |