Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL7028089

CC(C)(O)c1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[Br-]

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SNCA P37840 2/20 0.57
▸ HIF1A Q16665 1/20 0.38
▸ OPRD1 P41143 1/20 0.37
▸ KMT2A Q03164 3/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ NR1I2 O75469 1/20 0.35
▸ APP P05067 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ HSD11B1 P28845 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ GRIN2B Q13224 2/20 0.34
▸ PSMB5 P28074 1/20 0.34
▸ KCNH2 Q12809 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL6885441 0.86 SNCA (0.56) SNCAHIF1AALDH1A1TSHRLMNA
Bromide SCHEMBL16393752 0.83 SNCA (0.53) SNCAHIF1AAPPALDH1A1TSHR
Bromide SCHEMBL39844 0.81 SNCA (0.73) SNCAHIF1AAPPALDH1A1CYP1A2
Bromide SCHEMBL1840962 0.79 SNCA (0.56) SNCAHIF1AALDH1A1TSHRGRIN2B
Hydrochloric Acid SCHEMBL2446696 0.77 SNCA (0.69) SNCAHIF1AAPPALDH1A1CYP1A2
Iodide SCHEMBL9321342 0.77 SNCA (0.69) SNCAHIF1AAPPALDH1A1CYP1A2
Bromide SCHEMBL163158 0.77 SNCA (0.67) SNCAHIF1AAPPALDH1A1CYP1A2
Bromide SCHEMBL392314 0.76 SNCA (0.67) SNCAHIF1AAPPALDH1A1CYP1A2
Bromide SCHEMBL10011180 0.76 SNCA (0.67) SNCAHIF1AAPPALDH1A1CYP1A2
Bromide SCHEMBL2447513 0.76 SNCA (0.61) SNCAHIF1AKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6646143-B2 Anticancer agents; skin disorders LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 2003-11-11 — — US disclosed
US-20030004144-A1 Vitamin d analogues LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 2003-01-02 — — US disclosed
EP-1254111-A1 NOVEL VITAMIN D ANALOGUES Leo Pharma A/S (DK) 2002-11-06 — — EP disclosed
WO-2001051464-A1 NOVEL VITAMIN D ANALOGUES LEO PHARMA A/S (DK) 2001-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030004144-A1 Vitamin d analogues CYP24A1, CYP2R1, VDR SNCA 4773/4885HIF1A 914/4885OPRD1 622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.