Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.54 |
| ▸ | MMP2 | P08253 | 12/20 | 0.54 |
| ▸ | MMP3 | P08254 | 11/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | FCER2 | P06734 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20669159 | 0.83 | MMP1 (0.61) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL14932673 | 0.82 | MMP3 (0.52) | MMP1MMP2MMP3MMP7MMP9 | |
| Hydrochloric Acid SCHEMBL16228016 | 0.82 | MMP3 (0.51) | MMP1MMP2MMP3MMP7MMP9 | |
| Hydrochloric Acid SCHEMBL16228017 | 0.82 | MMP3 (0.51) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL2567392 | 0.80 | TSHR (0.54) | MMP1MMP2MMP3MMP9 | |
| SCHEMBL2567389 | 0.80 | TSHR (0.54) | MMP1MMP2MMP3MMP9 | |
| SCHEMBL6247713 | 0.80 | TSHR (0.54) | MMP1MMP2MMP3MMP9 | |
| SCHEMBL19360818 | 0.80 | MMP1 (0.60) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8764075 | 0.80 | MMP1 (0.59) | MMP1MMP2MMP3MMP7MMP9 | |
| Trifluoroacetic Acid SCHEMBL29076919 | 0.79 | CAPN1 (0.54) | MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |