Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996919 | 0.76 | DRD2 (0.62) | MTNR1AMTNR1BCA1CA2KMT2A | |
| SCHEMBL26763719 | 0.76 | MTNR1A (0.69) | MTNR1AMTNR1BCA1CA2MAOA | |
| SCHEMBL7140911 | 0.75 | MTNR1A (0.52) | MTNR1AMTNR1BTP53CYP1A2CYP3A4 | |
| SCHEMBL27451013 | 0.73 | MTNR1A (0.56) | MTNR1AMTNR1BTP53CYP1A2CYP3A4 | |
| SCHEMBL16691724 | 0.73 | MTNR1A (0.45) | MTNR1AMTNR1BTP53CYP1A2CYP3A4 | |
| SCHEMBL17530032 | 0.71 | GAA (0.60) | MTNR1AMTNR1BCA1CA2MEN1 | |
| SCHEMBL7336815 | 0.71 | GAA (0.60) | MTNR1AMTNR1BCA1CA2MEN1 | |
| SCHEMBL17530027 | 0.71 | GAA (0.60) | MTNR1AMTNR1BCA1CA2MEN1 | |
| SCHEMBL1970411 | 0.70 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2MAOA | |
| SCHEMBL30829050 | 0.70 | CHRM1 (0.44) | MTNR1AMTNR1BCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280759-A1 | OPTICALLY ACTIVE 2-AMINOTETRALIN DERIVATIVES, THE PROCESSES FOR THE PREPARATION THEREOF AND THE THERAPEUTICAL USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CHIESI FARMACEUTICI S.p.A. (IT) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085668-A1 | OPTICALLY ACTIVE 2-AMINOTETRALIN DERIVATIVES, THE PROCESSES FOR THE PREPARATION THEREOF AND THE THERAPEUTICAL USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CHIESI FARMACEUTICI S.P.A. (IT) | 2001-11-15 | — | — | WO | claimed |