Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028393 | 0.90 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2DRD3DRD2ALOX15 | |
| SCHEMBL6995973 | 0.84 | NPC1 (0.44) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL2956846 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2DRD3DRD2ALOX15 | |
| SCHEMBL6737586 | 0.80 | LMNA (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7033543 | 0.79 | CCR3 (0.48) | ALDH1A1SMN1; SMN2DRD3DRD2CD274 | |
| SCHEMBL2967585 | 0.78 | KCNH2 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7028488 | 0.77 | CD274 (0.61) | ALDH1A1DRD3CD274CCR3MKNK1 | |
| SCHEMBL7034957 | 0.77 | KDM4E (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL5965850 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2ALOX15NPC1RAB9A | |
| SCHEMBL6996059 | 0.77 | CCR3 (0.49) | ALDH1A1SMN1; SMN2DRD3DRD2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030212095-A1 | New bispidine compounds and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | US | disclosed |
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212095-A1 | New bispidine compounds and their use in the treatment of cardiac arrhythmias | KCNH1, LBR, CACNA1E | ALDH1A1 892/4885SMN1; SMN2 3890/4885DRD3 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.