Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025543 | 0.84 | HTR2A (0.52) | KCNH2HTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL7028380 | 0.79 | HTR2A (0.52) | KCNH2HTR2AHTR2CDRD2SSTR5 | |
| SCHEMBL7029502 | 0.77 | HTR2A (0.82) | KCNH2HTR2AHTR2CDRD2HTR7 | |
| SCHEMBL7027578 | 0.77 | KCNH2 (0.50) | KCNH2HTR2AHTR2CDRD2SSTR5 | |
| SCHEMBL7108529 | 0.77 | HTR2A (0.55) | KCNH2HTR2AHTR2CDRD2HTR7 | |
| SCHEMBL7033963 | 0.77 | RAB9A (0.52) | KCNH2CHRNA7SSTR5NR4A2 | |
| SCHEMBL7031444 | 0.76 | KCNH2 (0.51) | KCNH2HTR2AHTR2CDRD2HTR7 | |
| SCHEMBL7024062 | 0.76 | HTR2A (0.70) | KCNH2HTR2AHTR2CDRD2HTR7 | |
| SCHEMBL7023723 | 0.75 | HTR2A (0.59) | KCNH2HTR2AHTR2CDRD2HTR7 | |
| SCHEMBL7031756 | 0.75 | HTR2A (0.55) | KCNH2HTR2AHTR2CDRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | US | disclosed |
| EP-1246803-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT 2A? RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051469-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES WHICH FUNCTION AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2001-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | HTR2A, HTR1A, HTR5A | KCNH2 914/4885HTR2A 1/4885HTR2C 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.