Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127595 | 0.85 | SIRT1 (0.51) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7410585 | 0.84 | KMT2A (0.51) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7413500 | 0.84 | SIRT1 (0.50) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7407777 | 0.83 | NR2E1 (0.53) | KMT2AMEN1CHRNA7MAPT | |
| Hydrochloric Acid SCHEMBL7417242 | 0.82 | NR2E1 (0.52) | KMT2AMEN1CHRNA7MAPT | |
| SCHEMBL7410108 | 0.82 | HTR1D (0.58) | KMT2AMEN1HTR1BHTR1DCFTR | |
| SCHEMBL7406466 | 0.80 | KMT2A (0.50) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7411645 | 0.79 | HTR1B (0.49) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7413807 | 0.79 | KMT2A (0.46) | KMT2AMEN1HTR1BHTR1AHTR1D | |
| SCHEMBL7407819 | 0.79 | KMT2A (0.44) | KMT2AMEN1HTR1BHTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010122343-A1 | A PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND FROVATRIPTAN SUCCINATE AND THEIR SYNTHETIC INTERMEDIATES | GENERICS [UK] LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |
| EP-0674621-B1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | VERNALIS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-5962501-A | HEADACHES | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5917054-A | ALKYLATING ENANTIOMER OF 3-AMINO-6-CARBOXAMIDO-1,2,3,4-TETRAHYDROCARBAZOLE OR A SALT | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-06-29 | — | — | US | disclosed |
| US-5827871-A | VASODILATION DISORDERS, ESPECIALLY MIGRAINE HEADACHES; SIDE EFFECT REDUCTION | SMITHKLINE BEECHAM PLC (GB) | 1998-10-27 | — | — | US | disclosed |
| EP-0603432-B1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1998-10-21 | — | — | EP | disclosed |
| EP-0591280-B1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5650426-A | Enantiomers of carbazole derivatives as 5-HT.sub. 1-like agonists | SMITHKLINE BEECHAM PLC (GB) | 1997-07-22 | — | — | US | disclosed |
| US-5637611-A | Medicaments | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-06-10 | — | — | US | disclosed |
| US-5618947-A | SEPARATING THE RACEMIC MIXTURE BY CHROMATOGRAPHY | SMITHKLINE BEECHAM, P.L.C. (GB) | 1997-04-08 | — | — | US | disclosed |
| US-5618948-A | TREATMENT OF 6-CARBOXAMIDO-3-METHYLAMINO-1,2,3,4-TETRAHYDROCARBAZOLE WITH 2-PYRROLIDONE-5-CARBOXYLIC ACID, CRYSTALLIZATION | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-04-08 | — | — | US | disclosed |
| US-5616603-A | TREATING MIGRAINES | SMITHKLINE BEECHAM PLC (GB) | 1997-04-01 | — | — | US | disclosed |
| US-5464864-A | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-07 | — | — | US | disclosed |
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | disclosed |