Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.53 |
| ▸ | DRD3 | P35462 | 9/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | DRD5 | P21918 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029083 | 0.78 | DRD2 (0.47) | DRD2DRD3HTR1D | |
| SCHEMBL338383 | 0.74 | DRD2 (0.57) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL338382 | 0.74 | DRD2 (0.57) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL21590355 | 0.73 | DRD2 (0.64) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL6817140 | 0.71 | DRD2 (0.54) | DRD2DRD3DRD4 | |
| SCHEMBL840040 | 0.71 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL8155591 | 0.71 | DRD2 (0.54) | DRD2DRD3DRD4 | |
| SCHEMBL7245474 | 0.71 | DRD2 (0.54) | DRD2DRD3DRD4 | |
| SCHEMBL840041 | 0.71 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4 | |
| SCHEMBL7239637 | 0.70 | DRD2 (0.42) | DRD2DRD3HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |