Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816670 | 0.82 | DRD2 (0.48) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL8157601 | 0.82 | DRD2 (0.48) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7030108 | 0.82 | DRD2 (0.48) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL840757 | 0.78 | DRD2 (0.51) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7032090 | 0.78 | DRD2 (0.53) | DRD2DRD3HTR1D | |
| SCHEMBL4788734 | 0.78 | DRD2 (0.49) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7031018 | 0.77 | DRD2 (0.71) | DRD2DRD3 | |
| SCHEMBL6820053 | 0.77 | DRD2 (0.71) | DRD2DRD3 | |
| SCHEMBL6820475 | 0.76 | DRD2 (0.51) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL8158925 | 0.76 | HTR1A (0.65) | DRD2DRD3HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |