Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 11/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 5/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028281 | 0.79 | CTSD (0.42) | HTR2BSIGMAR1HTR1AKDM4EALDH1A1 | |
| SCHEMBL11455838 | 0.78 | HTR2B (0.48) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL8314935 | 0.77 | SCN9A (0.38) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL9832996 | 0.76 | HTR2B (0.46) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL8315522 | 0.75 | BACE1 (0.33) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL14031240 | 0.74 | TAAR1 (0.34) | — | |
| SCHEMBL5734820 | 0.72 | KMT2A (0.43) | HTR2BSIGMAR1HTR1AALDH1A1MAPT | |
| SCHEMBL31525286 | 0.72 | HTR2B (0.43) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL3378398 | 0.71 | KDM4E (0.45) | HTR2BSIGMAR1HTR1AHTR7TMEM97 | |
| SCHEMBL9385665 | 0.70 | HTR2B (0.44) | HTR2BSIGMAR1HTR1AHTR7TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596758-B1 | Treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds. | MERCK PATENT GMBH (DE) | 2003-07-22 | — | — | US | disclosed |
| EP-1140893-B1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-05 | — | — | EP | disclosed |