SCHEMBL7033155

SCHEMBL7033155

C=CCn1cnc2nc3cc(Cl)ccc3nc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.44
ALDH1A1 P00352 10/20 0.39
HPGD P15428 8/20 0.39
HSD17B10 Q99714 5/20 0.39
KDM4E B2RXH2 6/20 0.38
SMN1; SMN2 Q16637 5/20 0.36
GAA P10253 3/20 0.36
TP53 P04637 1/20 0.36
GLA P06280 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
MAPT P10636 3/20 0.35
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
PDE4B Q07343 1/20 0.34
PDE4D Q08499 1/20 0.34
LMNA P02545 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9843438 0.86 HIF1A (0.37) HIF1AALDH1A1HPGDHSD17B10KDM4E
SCHEMBL7034501 0.83 HPGD (0.55) HIF1AALDH1A1HPGDHSD17B10KDM4E
SCHEMBL7034506 0.82 DPP4 (0.42) ALDH1A1HSD17B10KDM4ECASP1CASP7
SCHEMBL7092147 0.77 TSHR (0.41) ALDH1A1HPGDHSD17B10KDM4EGAA
SCHEMBL10524592 0.76 TLR8 (0.40) ALDH1A1HPGDHSD17B10KDM4EGAA
SCHEMBL1539099 0.74 FGFR1 (0.46) HIF1AALDH1A1HSD17B10SMN1; SMN2GAA
SCHEMBL11727221 0.73 HPGD (0.45) ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2
Hydrochloric Acid SCHEMBL11725799 0.72 HPGD (0.44) ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2
SCHEMBL7036789 0.69 FGFR1 (0.56) ALDH1A1HPGDKDM4ECASP1CASP7
SCHEMBL4640511 0.69 ALDH1A1 (0.43) ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1291714-A1 An aqueous thermally bleachable composition useful in a photothermographic element EASTMAN KODAK COMPANY (US) 2003-03-12 EP disclosed
EP-1288709-A1 A thermally bleachable dye for a color photothermographic element EASTMAN KODAK COMPANY (US) 2003-03-05 EP disclosed
US-6492076-B1 UNDERGOES CHANGE IN ELECTROMAGNETIC ABSORPTION WHEN HEATED; ANTIHALATION OR FILTER LAYERS CONTAINING ZWITTERIONIC 1-AMINOPYRIDINIUM DYE EASTMAN KODAK COMPANY 2002-12-10 US disclosed
US-6451516-B1 AMINOPYRIDINIUM DYE WITH METHIN LINKAGE TERMINATED BY A HETEROCVYCLIC NUCLEUS AS FOUND IN CYANINE DYES EASTMAN KODAK COMPANY 2002-09-17 US disclosed
US-4075017-A Photothermographic material containing a combination of energy-sensitive organic dyes and process of forming a positive or negative image with the material EASTMAN KODAK COMPANY (US) 1978-02-21 US disclosed
US-RE29168-E HEAT SENSITIVE, ANTIHALATION LAYER EASTMAN KODAK COMPANY (US) 1977-04-05 US disclosed