Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261511 | 0.73 | MC4R (0.42) | HSD11B1CNR2POLBMAPK1 | |
| SCHEMBL1729214 | 0.73 | MC4R (0.42) | HSD11B1CNR2POLBMAPK1 | |
| SCHEMBL1728842 | 0.73 | MC4R (0.42) | HSD11B1CNR2POLBMAPK1 | |
| Ethyne SCHEMBL27849625 | 0.72 | HSD11B1 (0.53) | HSD11B1PPARGPPARACNR2DPP4 | |
| SCHEMBL163729 | 0.70 | HSD11B1 (0.55) | HSD11B1PPARGPPARACNR2DPP4 | |
| SCHEMBL29019503 | 0.70 | HSD11B1 (0.44) | HSD11B1DPP4ENPP1FFAR4SCN9A | |
| SCHEMBL10449366 | 0.70 | DPP4 (0.41) | PPARGPPARADPP4MAPK1PDCD1 | |
| SCHEMBL3790614 | 0.70 | ALDH1A1 (0.45) | HSD11B1DPP4ACHEENPP1FFAR4 | |
| SCHEMBL28053727 | 0.69 | FFAR4 (0.54) | HSD11B1PPARGPPARACNR2DPP4 | |
| SCHEMBL12261869 | 0.69 | SMN1; SMN2 (0.47) | HSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756384-B2 | TREATMENT OF DISEASES AND DISORDERS RELATED TO THE HISTAMINE H3 RECEPTOR. | NOVO NORDISK A/S (DK) | 2004-06-29 | — | — | US | disclosed |