SCHEMBL163729

SCHEMBL163729

FC(F)(F)c1ccccc1-c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.55
AR P10275 1/20 0.52
SCN9A Q15858 2/20 0.50
FFAR4 Q5NUL3 1/20 0.50
ALDH1A1 P00352 1/20 0.47
HPGD P15428 1/20 0.47
SLC13A5 Q86YT5 1/20 0.46
PPARG P37231 1/20 0.46
PPARA Q07869 1/20 0.46
KIF11 P52732 1/20 0.46
TRPA1 O75762 3/20 0.46
BACE1 P56817 1/20 0.46
TRPM8 Q7Z2W7 1/20 0.46
NOTUM Q6P988 1/20 0.46
CNR2 P34972 1/20 0.45
DPP4 P27487 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL28126322 0.98 HSD11B1 (0.53) HSD11B1ARSCN9AFFAR4ALDH1A1
Ethyne SCHEMBL27849625 0.98 HSD11B1 (0.53) HSD11B1ARSCN9AFFAR4ALDH1A1
Methane SCHEMBL28022370 0.98 HSD11B1 (0.53) HSD11B1ARSCN9AFFAR4ALDH1A1
Water SCHEMBL27916635 0.98 AR (0.55) HSD11B1ARSCN9AFFAR4ALDH1A1
Water SCHEMBL7091891 0.98 AR (0.55) HSD11B1ARSCN9AFFAR4ALDH1A1
Hydrogen Sulfide SCHEMBL27686805 0.98 HSD11B1 (0.53) HSD11B1ARSCN9AFFAR4ALDH1A1
SCHEMBL11286015 0.95 KIF11 (0.54) HSD11B1ARSCN9AFFAR4ALDH1A1
SCHEMBL5523215 0.95 KIF11 (0.54) HSD11B1ARSCN9AFFAR4ALDH1A1
SCHEMBL29980535 0.95 KIF11 (0.54) HSD11B1ARSCN9AFFAR4ALDH1A1
Fluoride SCHEMBL27890489 0.95 HSD11B1 (0.51) HSD11B1ARSCN9AFFAR4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1607 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118852587-A Synthesis method of novel high-temperature-resistant trifluoromethyl biphenyl epoxy resin 复旦大学 2024-10-29 CN claimed
CN-116479659-B Polyamide imide-polyaniline composite conductive fiber membrane with high glass transition temperature and preparation method thereof 浙江大学 2024-05-24 CN claimed
US-20240150524-A1 POLYIMIDES HAVING LOW DIELECTRIC LOSS SOLVAY SPECIALTY POLYMERS ITALY S.P.A. (IT) 2024-05-09 US claimed
CN-117924699-A Polyimide precursor and polyimide resin composition 旭化成株式会社 2024-04-26 CN claimed
CN-114539194-B Synthesis method of 2,2' -di (trifluoromethyl) -4,4', 5' -biphenyl dianhydride 常州市阳光药业有限公司 2024-03-29 CN claimed
CN-114761487-B Polymer composition, liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element, and method for manufacturing liquid crystal display element 日产化学株式会社 2024-02-20 CN claimed
US-11905230-B2 Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament CHINA PHARMACEUTICAL UNIVERSITY (CN) 2024-02-20 US claimed
CN-117384121-A Preparation method of 2,2' -di (trifluoromethyl) -4,4', 5' -biphenyl dianhydride 中国科学院上海有机化学研究所 2024-01-12 CN claimed
CN-113874419-B Polyimide precursor and polyimide resin composition 旭化成株式会社 2024-01-09 CN claimed
CN-117343318-A Fluorine-containing polyamide and preparation method thereof 宁波斯乃隆材料科技有限公司 2024-01-05 CN claimed
US-20050075324-A1 Melanin concentrating hormone antagonists THE PROCTER & GAMBLE COMPANY (US) 2005-04-07 US claimed
CN-1603354-A Process for synthesis of sulfonated polyimide proton transmission film CHANGCHUN APPLIED CHEMISTRY (CN) 2005-04-06 CN claimed
WO-2005023735-A2 CARBON-CARBON BOND CREATION METHOD COMPRISING THE COUPLING OF A TRANSFERABLE GROUP AND AN ACCEPTOR GROUP RHODIA CHIMIE (FR) 2005-03-17 WO claimed
CN-1576293-A Process for producing solvent-soluble polyimide MITSUBISHI GAS CHEMICAL CO (JP) 2005-02-09 CN claimed
CN-1491251-A Photoactive polymer 2004-04-21 CN claimed
CN-1468907-A Photosensitive polyimide resin precursor composition, optical polyimide, light wave guide tube and process for producing the same light wave guide tube �ն��繤��ʽ���� 2004-01-21 CN claimed
EP-1368411-A1 PHOTOACTIVE POLYMER Rolic AG (CH) 2003-12-10 EP claimed
CN-1442466-A Liquid crystal orientation agent, formation method of liquid crystal orientation membrane and liquid crystal display unit JSR CORP (JP) 2003-09-17 CN claimed
WO-2002062873-A9 PHOTOACTIVE POLYMER ROLIC AG (CH) 2002-10-03 WO claimed
WO-2002062873-A1 PHOTOACTIVE POLYMER ROLIC AG (CH) 2002-08-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050075324-A1 Melanin concentrating hormone antagonists MCHR1, MCHR2, MC1R HSD11B1 330/4885AR 382/4885SCN9A 4454/4885
US-11905230-B2 Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament SLC5A1, PYGL, GPR119 HSD11B1 329/4885AR 2759/4885SCN9A 3648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.