Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035541 | 0.84 | ADORA1 (0.45) | ADORA1PTGDR2PDE5APDE3AKDM4E | |
| SCHEMBL7038368 | 0.81 | ADORA1 (0.48) | ADORA1PTGDR2PDE5APDE3AKDM4E | |
| SCHEMBL7036909 | 0.78 | ADORA1 (0.43) | ADORA1PDE5APDE3AKDM4ECYP1A2 | |
| SCHEMBL7036654 | 0.77 | ADORA1 (0.44) | ADORA1PTGDR2PDE5APDE3A | |
| SCHEMBL7035962 | 0.77 | ADORA1 (0.43) | ADORA1PTGDR2PDE5APDE3AKDM4E | |
| SCHEMBL7033864 | 0.74 | ADORA1 (0.38) | ADORA1PDE5APDE3A | |
| SCHEMBL7039890 | 0.73 | PDE5A (0.42) | ADORA1PDE5APDE3ACYP1A2TSHR | |
| SCHEMBL7292709 | 0.69 | ADORA1 (0.69) | ADORA1KDM4EHTTTSHRMAPK1 | |
| SCHEMBL7032871 | 0.69 | PDE3A (0.65) | ADORA1PDE5APDE3ACYP1A2TSHR | |
| SCHEMBL19829272 | 0.67 | ADORA1 (0.86) | ADORA1KDM4EHTTHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003004494-A1 | PYRIDAZINONE COMPOUND AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-16 | — | — | WO | disclosed |