Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034529 | 0.81 | ADORA2B (0.55) | POLBNCOA1NCOA3HTTUSP2 | |
| SCHEMBL7039451 | 0.74 | ADORA2B (0.86) | POLBHTTUSP2ALDH1A1ADORA2B | |
| SCHEMBL16028050 | 0.72 | TRPC4 (0.52) | POLBALDH1A1LMNAMAPK1MAPT | |
| SCHEMBL5718940 | 0.71 | USP2 (0.72) | POLBNCOA1NCOA3HTTUSP2 | |
| SCHEMBL16076079 | 0.70 | TRPC4 (0.52) | HTTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL5411870 | 0.69 | ADORA2B (1.00) | POLBALDH1A1ADORA2BSMN1; SMN2HSD17B10 | |
| SCHEMBL13977076 | 0.67 | POLB (0.80) | POLBNCOA1NCOA3HTTUSP2 | |
| SCHEMBL19666778 | 0.67 | ALDH1A1 (0.68) | POLBNCOA1NCOA3HTTALDH1A1 | |
| SCHEMBL16029530 | 0.66 | SMN1; SMN2 (0.56) | POLBHTTALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5639709 | 0.65 | DPP4 (0.74) | HTTUSP2ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956855-B1 | Immunosuppressive effects of 8 substituted xanthine derivatives | LEUVEN K U RES & DEV (BE) | 2003-03-12 | — | — | EP | claimed |