Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15437888 | 1.00 | CES1 (0.43) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL4631961 | 0.86 | PTGS2 (0.54) | CYP3A4PTGS2ESR1CYP19A1ESR2 | |
| SCHEMBL10723348 | 0.84 | PTGS2 (0.38) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL25455453 | 0.84 | PTGS2 (0.42) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL21627081 | 0.78 | TSHR (0.45) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL21588951 | 0.78 | TSHR (0.45) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL25455100 | 0.78 | TSHR (0.45) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL24758900 | 0.78 | TSHR (0.45) | CES1TDP1MAPK1CYP3A4MAPT | |
| SCHEMBL3122443 | 0.77 | PTGS2 (0.68) | PTGS2ESR2 | |
| SCHEMBL8422581 | 0.77 | PTGS2 (0.68) | PTGS2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296690-B2 | Method for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof | METACINE, INC. (KR) | 2016-03-29 | — | — | US | disclosed |
| US-20140275203-A1 | Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof | METACINE, INC. (KR) | 2014-09-18 | — | — | US | disclosed |
| US-20140031563-A1 | New compounds for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof | METACINE, INC. (KR) | 2014-01-30 | — | — | US | disclosed |
| US-20030065117-A1 | Modified silicone compound, process of producing the same, and cured object obtained therefrom | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2003-04-03 | — | — | US | disclosed |
| EP-0799261-B1 | PROCESS FOR PREPARATION OF ALLYL ETHER, THIOETHER AND AMINE COMPOUNDS | DOW CHEMICAL CO (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0799261-A1 | PROCESS FOR PREPARATION OF ALLYL ETHER, THIOETHER AND AMINE COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996020232-A1 | PROCESS FOR PREPARATION OF ALLYL ETHER, THIOETHER AND AMINE COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1996-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031563-A1 | New compounds for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof | SOST, MYD88, MSR1 | CES1 1337/4885TDP1 2337/4885MAPK1 519/4885 |
| US-20030065117-A1 | Modified silicone compound, process of producing the same, and cured object obtained therefrom | ORMDL3, SGMS1, HEATR1 | CES1 940/4885TDP1 4547/4885MAPK1 1384/4885 |
| US-20140275203-A1 | Method for Inhibiting Differentiation of Osteoclast and Pharmaceutical Composition Comprising Thereof | SOST, MYD88, MSR1 | CES1 484/4885TDP1 2607/4885MAPK1 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.