Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382571 | 0.94 | HDAC1 (0.48) | HDAC1HDAC3NCOR2HDAC2HDAC10 | |
| SCHEMBL7035699 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HPGDCYP3A4 | |
| SCHEMBL15753134 | 0.79 | HDAC1 (0.46) | HDAC1HDAC3NCOR2HDAC2HDAC10 | |
| SCHEMBL7336752 | 0.75 | SHMT2 (0.51) | HDAC1HDAC3NCOR2NPC1RAB9A | |
| SCHEMBL2370574 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1HPGDCYP3A4 | |
| SCHEMBL1329140 | 0.71 | HDAC1 (0.52) | HDAC1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3811403 | 0.71 | NPC1 (0.68) | HDAC1HDAC3NCOR2HDAC2HDAC10 | |
| Hydrochloric Acid SCHEMBL8696150 | 0.70 | HDAC1 (0.51) | HDAC1NPC1RAB9AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1880511 | 0.70 | HDAC1 (0.51) | HDAC1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL14433363 | 0.68 | HDAC1 (0.52) | HDAC1NPC1RAB9AALDH1A1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575361-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8513434-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20110237635-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | HDAC1 3742/4885HDAC3 3560/4885NCOR2 1743/4885 |
| US-20110237635-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | HDAC1 3742/4885HDAC3 3560/4885NCOR2 1743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.