Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029058 | 0.82 | CTSK (0.49) | CTSLCTSSCTSKEPHX2EPHX1 | |
| SCHEMBL5934662 | 0.74 | CTSS (0.57) | CTSLCTSSCTSKMMP1MMP2 | |
| SCHEMBL7033255 | 0.74 | CTSS (0.57) | CTSLCTSSCTSKMMP1MMP2 | |
| SCHEMBL7479457 | 0.67 | CTSL (0.40) | CTSLCTSSCTSKALDH1A1CYP2C19 | |
| SCHEMBL7397032 | 0.65 | CTSK (0.69) | CTSLCTSSCTSKEPHX1ALDH1A1 | |
| SCHEMBL4331121 | 0.63 | EPHX2 (0.45) | EPHX2EPHX1ALDH1A1CYP2C19NPC1 | |
| SCHEMBL7474486 | 0.63 | CTSK (0.61) | CTSLCTSSCTSKMMP2 | |
| SCHEMBL17568771 | 0.63 | EPHX2 (0.47) | EPHX2EPHX1ALDH1A1CYP2C19NPC1 | |
| SCHEMBL3450460 | 0.60 | EPHX2 (0.52) | EPHX2EPHX1ALDH1A1CYP2C19NPC1 | |
| SCHEMBL10634672 | 0.60 | EPHX2 (0.48) | CTSLCTSSCTSKEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929571-B1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2003-02-26 | — | — | EP | disclosed |
| US-6034077-A | BONE DISORDERS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2000-03-07 | — | — | US | disclosed |
| EP-0929571-A1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (CA) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998012210-A1 | 4-SUBSTITUTED-3-(2-AMINO-2-CYCLOALKYL METHYL)-ACETAMIDO AZETIDIN-2-ONE DERIVATIVES AS CYSTEINE PROTEINASE REGULATORS | SYNPHAR LABORATORIES INC. (US) | 1998-03-26 | — | — | WO | disclosed |