Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30834248 | 1.00 | KMT2A (0.52) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL9221702 | 0.83 | ACHE (0.50) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL5859196 | 0.83 | KMT2A (0.48) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL8911487 | 0.80 | KMT2A (0.56) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL15519819 | 0.80 | KMT2A (0.56) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL17515294 | 0.78 | ACHE (0.55) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL11459078 | 0.76 | ACHE (0.43) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL31293260 | 0.75 | KMT2A (0.51) | KMT2AALDH1A1KDM4EACHEBUB1 | |
| SCHEMBL5889332 | 0.75 | FAAH (0.44) | KMT2AALDH1A1KDM4EACHEMAPT | |
| SCHEMBL9218363 | 0.75 | FAAH (0.44) | KMT2AALDH1A1KDM4EACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030158266-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. | 2003-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158266-A1 | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies | AADAT, IL2, TPMT | KMT2A 1188/4885ALDH1A1 3241/4885KDM4E 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.