Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.69 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.69 |
| ▸ | BAX | Q07812 | 1/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 4/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27090262 | 0.94 | ESR1 (0.61) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL21311877 | 0.94 | ESR1 (0.61) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL27090234 | 0.94 | LTA4H (0.64) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL9292956 | 0.89 | HSD17B1 (0.68) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL21311926 | 0.89 | HSD17B1 (0.61) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL10453614 | 0.88 | FFAR4 (0.61) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL19891793 | 0.88 | FFAR4 (0.61) | LTA4HNR1H2BAXFFAR1FFAR4 | |
| SCHEMBL11426529 | 0.88 | LTA4H (0.82) | LTA4HNR1H2BAXESR1ESR2 | |
| SCHEMBL9588710 | 0.88 | LTA4H (0.82) | LTA4HNR1H2BAXESR1ESR2 | |
| SCHEMBL4536542 | 0.88 | LTA4H (0.60) | LTA4HNR1H2BAXFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944636-B1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0946495-B1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6353128-B1 | FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK. | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0946495-A4 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0946495-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5916922-A | FOR INHIBITING HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1998024756-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |