Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piposulfan SCHEMBL4636 | 0.80 | ALDH1A1 (0.43) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL13187892 | 0.79 | HPGD (0.46) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL10862611 | 0.79 | HPGD (0.46) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| Piposulfan SCHEMBL28095073 | 0.77 | ALDH1A1 (0.41) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL18526705 | 0.77 | ATM (0.65) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| Piposulfan SCHEMBL14874457 | 0.76 | ALDH1A1 (0.41) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL10722542 | 0.75 | ATM (0.85) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL19574089 | 0.75 | ATM (0.95) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL28366947 | 0.75 | ATM (0.85) | ATMKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL27487132 | 0.75 | ATM (0.85) | ATMKMT2AMEN1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030149269-A1 | Substituted piperidine derivatives | RAE DUNCAN ROBERTSON (GB) | 2003-08-07 | — | — | US | disclosed |
| US-20020165395-A1 | Substituted piperidine derivatives | RAE DUNCAN ROBERTSON (GB) | 2002-11-07 | — | — | US | disclosed |
| US-20020087001-A1 | Substituted piperidine derivatives | RAE DUNCAN ROBERTSON (GB) | 2002-07-04 | — | — | US | disclosed |
| US-6365604-B1 | Antipsychotic substituted piperidine derivatives | AKZO NOBEL NV (NL) | 2002-04-02 | — | — | US | disclosed |
| CN-1274357-A | Antipsychotic substituted piperidine derivatives | AKZO NOBEL NV (NL) | 2000-11-22 | — | — | CN | disclosed |
| EP-1021440-A2 | ANTIPSYCHOTIC SUBSTITUTED PIPERIDINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019324-A2 | ANTIPSYCHOTIC SUBSTITUTED PIPERIDINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 1999-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020087001-A1 | Substituted piperidine derivatives | DRD2, GRIN2C, DRD4 | ATM 4405/4885KMT2A 1744/4885MEN1 4589/4885 |
| US-20030149269-A1 | Substituted piperidine derivatives | DRD2, GRIN2C, DRD4 | ATM 4405/4885KMT2A 1744/4885MEN1 4589/4885 |
| US-20020165395-A1 | Substituted piperidine derivatives | DRD2, GRIN2C, DRD4 | ATM 4405/4885KMT2A 1744/4885MEN1 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.