Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.46 |
| ▸ | MMP3 | P08254 | 5/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | MMP7 | P09237 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027257 | 0.89 | MMP1 (0.53) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6075256 | 0.88 | MMP1 (0.48) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6075762 | 0.76 | MMP1 (0.52) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6076884 | 0.76 | MMP1 (0.53) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6076358 | 0.76 | MMP1 (0.53) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6076182 | 0.76 | MMP1 (0.53) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7357966 | 0.74 | MMP1 (0.47) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7033779 | 0.74 | MMP1 (0.44) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL7362860 | 0.71 | MMP1 (0.41) | MMP1MMP3MMP13MMP7MMP9 | |
| SCHEMBL6077502 | 0.71 | FKBP1A (0.54) | MMP1MMP3MMP13MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042297-B1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC (US) | 2003-02-26 | — | — | EP | claimed |