Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.44 |
| ▸ | MMP9 | P14780 | 10/20 | 0.44 |
| ▸ | MMP8 | P22894 | 7/20 | 0.44 |
| ▸ | MMP13 | P45452 | 6/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 8/20 | 0.42 |
| ▸ | MMP7 | P09237 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075423 | 0.89 | MMP1 (0.45) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL6075492 | 0.75 | MMP1 (0.45) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL7036112 | 0.74 | MMP1 (0.46) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL7027257 | 0.72 | MMP1 (0.53) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL6075460 | 0.71 | MMP1 (0.43) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL7031074 | 0.70 | SMN1; SMN2 (0.50) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL7028577 | 0.70 | HCRTR1 (0.46) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL6075584 | 0.70 | ALDH1A1 (0.42) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL7420859 | 0.69 | MMP3 (0.41) | MMP1MMP9MMP8MMP13MMP2 | |
| SCHEMBL6076042 | 0.69 | CA12 (0.53) | MMP1MMP9MMP13MMP2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042297-B1 | CARBOXYL ACID SUBSTITUTED HETEROCYCLES AS METALLOPROTEINASE INHIBITORS | AMGEN INC (US) | 2003-02-26 | — | — | EP | claimed |